Abstract
Phytochemical investigation of the stem bark extract of Boswellia papyrifera afforded two new stilbene glycosides, trans-4',5-dihydroxy-3-methoxystilbene-5-O-{alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (1), trans-4',5-dihydroxy-3-methoxystilbene-5-O-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (2), and a new triterpene, 3alpha-acetoxy-27-hydroxylup-20(29)-en-24-oic acid (3), along with five known compounds, 11-keto-beta-boswellic acid (4), beta-elemonic acid (7), 3alpha-acetoxy-11-keto-beta-boswellic acid (8), beta-boswellic acid (9), and beta-sitosterol (10). The stilbene glycosides exhibited significant inhibition of phosphodiesterase I and xanthine oxidase. The triterpenes (3-9) exhibited prolyl endopeptidase inhibitory activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Boswellia / chemistry*
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Cameroon
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Inhibitory Concentration 50
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Molecular Structure
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Plants, Medicinal / chemistry*
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Stilbenes / chemistry
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Stilbenes / isolation & purification*
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Stilbenes / pharmacology
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
Substances
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Enzyme Inhibitors
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Glycosides
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Stilbenes
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Triterpenes
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trans-4',5-dihydroxy-3-methoxystilbene-5-O-(alpha-L-rhamnopyranosyl-(1-2)-alpha-L-rhamnopyranosyl-(1-6))-beta-D-glucopyranoside
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trans-4',5-dihydroxy-3-methoxystilbene-5-O-(alpha-L-rhamnopyranosyl-(1-6))-beta-D-glucopyranoside